Innate Lymphoid Cells: The Hidden Actors in Skin Disorders
نویسندگان
چکیده
منابع مشابه
Innate Lymphoid Cells in the Skin
Innate lymphoid cells (ILCs) are part of a heterogeneous family of innate immune cells with newly identified roles in mediating immunity, tissue homeostasis, and pathologic inflammation. Here, we review recent studies delineating the roles of ILCs in the pathogenesis of multiple inflammatory skin disorders and their unique effector functions. Finally, we address how these studies have informed ...
متن کاملInnate lymphoid cells and the skin
Innate lymphoid cells are an emerging family of effector cells that contribute to lymphoid organogenesis, metabolism, tissue remodelling and protection against infections. They maintain homeostatic immunity at barrier surfaces such as lung, skin and gut (Nature 464:1367-1371, 2010, Nat Rev Immunol 13: 145-149, 2013). Several human and mouse studies suggest a role for innate lymphoid cells in in...
متن کاملInnate lymphoid cells
Purpose of review: The purpose of this article is to review recent advances in our understanding of innate lymphoid cell function and to speculate on how these cells may become activated and influence the immune response to allogeneic tissues and cells following transplantation. Recent findings: Innate lymphoid cells encompass several novel cell types whose wide ranging roles in the immune syst...
متن کاملHuman innate lymphoid cells.
Innate lymphoid cells (ILCs) are lymphoid cells that do not express rearranged receptors and have important effector and regulatory functions in innate immunity and tissue remodeling. ILCs are categorized into 3 groups based on their distinct patterns of cytokine production and the requirement of particular transcription factors for their development and function. Group 1 ILCs (ILC1s) produce i...
متن کاملHiJAKing Innate Lymphoid Cells?
The family of innate lymphoid cells (ILCs) consists of a heterogeneous group of cytokine-producing cells that have features in common with adaptive T helper (Th) cells. Cytokines acting through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways are key players in both Th and ILC biology. Observations in animal models, supported by evidence from humans, have ...
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ژورنال
عنوان ژورنال: Clinical Dermatology Open Access Journal
سال: 2016
ISSN: 2574-7800
DOI: 10.23880/cdoaj16000101